Thank you for your comments. When we talk about chronic glaucoma, we should always keep in mind one most important established fact: that the arcuate and peripheral fibers are selectively destroyed first in the early stages whereas the central vision fibers last until the end stage of glaucoma. I think perhaps this is the only lead we have in discovering the pathogenesis of glaucoma. Based on selective destruction of arcuate and peripheral fibers in early stages, glaucoma just could not be a neurodegenerative disease. In my opinion a neurodegenerative disease will occur generalized or randomly but to specifically start first with those ganglion cells of the retina or of the neurons of the lateral geniculate nucleus which serve the arcuate or peripheral fibers will be most unlikely.

My hypothesis that the optic disc may be sinking or in other words herniating in the scleral canal is based on selective destruction of the arcuate and peripheral fibers in the early stages of glaucoma. There are two main points in my hypothesis. One is that optic disc is sinking and secondly due to sinking the axons are being severed (not atrophy). Glaucoma may not be neuropathy but axotomy of the optic disc. My sinking disc hypothesis will attempt to answer all the unanswered questions of glaucoma. You may like to visit my website: hasnaineye.com where I have put forward my arguments in favor of sinking disc hypothesis. But you are the judge